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Keep away from concomitant utilization of tucatinib with CYP3A substrates, in which minimum concentration modifications may bring on really serious or life-threatening toxicities. If unavoidable, lessen CYP3A substrate dose according to product labeling.Resulting from lengthy-acting metabolite, not regarded a drug of choice while in the elderly; co

phenytoin will minimize the extent or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.diazepam will enhance the stage or effect of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. If coadministration of lonafarnib (a delicate CYP3A substrate) wi